BGC > Produktsuche > I-BET 151 hydrochloride | 1300031-49-5

Molecular Formula: C23H21N5O3
Molecular Weight: 415.44454
Hazard Symbols: T
UN Number: UN 2811 6.1 / PGIII
WGKGermany: 3

Description:
I-BET151 is a BET bromodomain inhibitor, which blocks recruitment of BET to chromatin. It was shown to induce early cell cycle arrest and apoptosis in human and mouse MLL-fusion leukemia cell lines.

• Molecular Weight:415.453
• Melting Point:273-277°C
• Purity:>98%

Molecular Formula:
C23H21N5O3
Canonical SMILES:
CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)C(C)C5=CC=CC=N5)OC
InChI:
InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
InChIKey:
VUVUVNZRUGEAHB-CYBMUJFWSA-N
Appearance:
Off-white Solid
Synonyms:
GSK1210151A; 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one